How Democracy Ends

How do the ends replicate?

20 Schmeing, T.M. et al. (2005) An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA. Nature 438, 520–524 21 Weixlbaumer, A. et al. (2008) Insights into translational termination from the structure of RF2 bound to the ribosome. Science 322, 953–956 22 Laurberg, M. et al. (2008) Structural basis for translation termination on the 70S ribosome. Nature...

DNA repair: How Ku makes ends meet

The recently determined crystal structure of the Ku heterodimer, in both DNA-bound and unbound forms, has shed new light on the mechanism by which this protein fulfills its key role in the repair of DNA double-strand breaks.

Review of “The People Vs Tech: How the Internet is Killing Democracy (and How We Save It)” by Jamie Bartlett

The People Vs Tech: How the Internet is Killing Democracy (and How We Save It) by Jamie Bartlett. New York: Dutton, 2018. 256 pp., £8.99 (p/b), ISBN 978-1785039065.

How do tumors make ends meet?

W Barbara McClintock irradiated strains of Indian corn in the early 30s, she identified ring chromosomes, which she soon realized were a special case of chromosomes broken by radiation; the broken ends sometimes fused to one another and formed a ring (1, 2). This discovery led McClintock to hypothesize the existence of a special structure at the chromosome tip that would maintain chromosome sta...

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